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CEO and Business Director of the Medical Lex Information

Pharmacist Biochemist (1984) with Master’s degree (1996) and PhD in Pharmacology by the Federal University of Santa Catarina and Maximilian Universität München (2005). Pharmacy course coordinator at UNISUL (1996-2006) and Pharmacy course at UNIBAVE (2006-2010). Coordinator of the Biomedicine Research and Development Group, in the Professional Master’s Program in Pharmacy at UNIBAN (SP) (2006-2016). Coordinator of the Medical Specialization at Medical Lex / ISEPE and of the courses in Clinical Phytotherapy and Clinical Pharmacy in several states of Brazil (2012-current). CEO and Business Director of the Medical Lex Information Management and Courses Ltda. He has experience in the area of Pharmacology, with emphasis in Pharmacology Biochemistry and Molecular of Medicinal Plants. Acting mainly in the subjects: Mechanism of action of Medicinal Plants and Natural Products, Inflammation and its pharmaco-dynamic mechanisms.

Registered patents:

MARCUCCI, Maria Cristina; PAULINO, NIRALDO. Formulations based on propolis for dental use. 2001, Brazil. Patent: Privilege of Innovation. Record number: PI0105471, title: “Propolis-based formulations for dental use”, Institution of registration: INPI – National Institute of Industrial Property. Deposit: 09/26/2001; Concession: 03/08/2015.

PAULINO, N .; SCREMIN, A.. Vaginal gel of propolis typified for the treatment of disease of the female genital system. 2009, Brazil. Patent: Utility Model. Record number: PI0904121, title: “Propolis vaginal gel typified for the treatment of female genital system disease”, Institution of registration: INPI – National Institute of Industrial Property. Deposit: 01/10/2009; Concession: 08/02/2011.

PEREIRA, R.M.S. ; NOVAK, E. M.; OKUYAMA, C.E.; PAULINO, NIRALDO; BYDLOWSKI, S.P. Method of Obtaining Zinc Routine Coordination Complexes, Pharmaceutical and / or Cosmetic Composition and Their Uses. 2011, Brazil. Patent: Utility Model. Title: METHOD OF OBTAINING ZINC ROUTER COORDINATION COMPOUNDS, PHARMACEUTICAL AND / OR COSMETIC COMPOSITION AND ITS USES “, Registration Institution: INPI – National Institute of Industrial Property. Deposit: 06/01/2011; Concession: 02/18/2014.

MARCUCCI, M.C.; SANTOS, A.M.; PAULINO, NIRALDO. Cosmetic and pharmaceutical formulations based on coffee oil and propolis. 2012, Brazil. Patent: Utility Model. Number of the record: PI102012019950, title: “‘Cosmetic and pharmaceutical formulations based on coffee oil and propolis”, Registration institution: INPI – National Institute of Industrial Property. Deposit: 09/08/2012; Concession: 06/05/2014.

 

Latest scientific articles (last five year):

SOARES, A.C.; CARNEIRO, F. P.; FARO, L. R. F.; SILVA, M. V.; EUDES-FILHO, J.; ASSIS, M.S.; COSTA, F. J. Q.; SOUSA, J.B.; PAULINO, NIRALDO; MOTOYAMA, A. B.; AMARAL, K.; JREIGE JR, A.; FERREIRA, V.M. Therapeutic property of propolis extract in systemic infection induced in rats. INTERNATIONAL JOURNAL OF DEVELOPMENT RESEARCH, v. 7, p. 13381-13387, 2017.

VEIGA, R.S.; DE MENDONÇA, S.; MENDES, P.B. ; PAULINO, N.; MIMICA, M.J.; LAGAREIRO NETTO, A.A.; LIRA, I.S. ; LÓPEZ, B.G.-C. ; Negrão, V.; MARCUCCI, M.C. Artepillin C and phenolic compounds responsible for antimicrobial and antioxidant activity of green propolis and Baccharis dracunculifolia DC. JOURNAL OF APPLIED MICROBIOLOGY, v. 122, p. 911-920, 2017.

DE FIGUEIREDO, SONIA M.; BINDA, NANCY S.; VIEIRA-FILHO, SIDNEY A.; OF MOURA ALMEIDA, BRUNO; ABREU, SHEILA R.L.; PAULINO, NIRALDO; PASTORE, GLAUCIA M.; SATO, HELIA H.; THEODOROPOULOS, VIVIANE C.T.; TAPIA, EULALIA V.; PARK, YONG K.; CALIGIORNE, RACHEL B.. Physicochemical Characteristics of Brazilian Green Propolis Evaluated During a Six-Year Period. CURRENT DRUG DISCOVERY TECHNOLOGIES, v. 14, p. 127-134, 2017.

PAULINO, NIRALDO; PAULINO, AMARILIS SCREMIN; DINIZ, SUSANA N.; MENDONÇA, SERGIO DE; GONÇALVES, IVAIR D.; FLORES, FERNANDA FAIÃO; SANTOS, REGINALDO PEREIRA; RODRIGUES, CARINA; PARDI, PAULO CELSO; SUAREZ, JOSÉ AGUSTIN QUINCOCES. Evaluation of the anti-inflammatory action of curcumin analog (DM1): effect on iNOS and COX-2 gene expression and autophagy pathways. Bioorganic & Medicinal Chemistry (Print), v. 24, p. 1927-1935, 2016.

PAULINO, NIRALDO; COUTINHO, L.A .; VILELA, G.C.; LEANDRO, V. P. S.; PAULINO, A. S.. Antiulcerogenic effect of Brazilian propolis formulation in mice. Pharmacology & Pharmacy, v. 6, p. 32-36, 2015.

PAULINO, NIRALDO; BARBOSA, A. P.; PAULINO, A. S.; MARCUCCI, M.C. Hepatoprotective effect of green propolis is related to antioxidant action in vivo and in vitro. Oxidants and Antioxidants in Medical Science, v. 3, p. 43, 2014.

MIYASHIRO, C.A.H.V. ; DINIZ, S. N.; OLIVEIRA, D.A. F.; GONCALVES, I.D.; PEREIRA, R.M.S. ; SILVA, R.G.; PAULINO, NIRALDO; OKUYAMA, C.E. The Potentiation of Anti-inflammatory Effect and INOS and COX-2 Gene Expression Inhibition by Rut in Complexed with Cooper. British Journal of Medicine and Medical Research, v. 4, p. 1-10-10, 2014.

ANIDO-ANIDO, A.; LEWGOY, H. R.; R, M.; ALONSO, R.C.B.; MARCUCCI, M.C.; PAULINO, NIRALDO; BRETZ, W.A. Randomized, Double-masked, Placebo-controlled Clinical Trial on the Effects of Propolis and Chlorhexidine Mouthrinses on Gingivitis. Brazilian Dental Science, v. 17, p. 11-15, 2014.

BRETZ, WALTER A.; PAULINO, NIRALDO; NÖR, JACQUES E.; MOREIRA, ALEXANDRE. The Effectiveness of Propolis on Gingivitis: A Randomized Controlled Trial. The Journal of Alternative and Complementary Medicine (New York, N.Y.), v. 1, p. 141107141656007-5, 2014.

MARCUCCI, M.C.; SAWAYA, A.C.H.F. ; PAULINO, NIRALDO; DINIZ, S. N.; MENDONÇA, S.; RODRIGUES, N.C.; CASSINA-LOPES, B. G.. Chemical composition, biological activity and safety of use of red propolis .. Message Doce (Paulista Association of Beekeepers, Breeders of European Melon Bees), v. 125, p. 1-6, 2014.

PAULINO, N .; Coutinho, J.R.; COUTINHO, L.A.; PAULINO, S. A. Clinical evaluation of the anti-inflammatory effect of Baccharis dracunculifolia propolis gel on cervicitis. Revista Ciência e Estudos Acadêmicos de Medicina, v. 2, p. 31-46, 2014.